Intraocular pressure is comprised of four distinct components that, combined, lead to total intraocular pressure (IOP). These four components are currently best described by the modified Goldmann equation, which includes contributions from the Aqueous Humor Inflow Rate (Q), Uveoscleral Outflow Rate (U), Conventional Outflow Facility (C), and Episcleral Venous Pressure (EVP). EVP is the largest component of IOP, contributing around 2/3 of total IOP. However, no approved therapy to date selectively targets EVP.
Modified Goldmann Equation for IOP
Aqueous Humor Inflow Rate
Uveoscleral Outflow Rate
- Latanoprostene bunod
Conventional Trabecular Outflow Facility
Episcleral Venous Pressure
Selectively targeted by QLS-111
|Discovery||Pre-clinical||IND-Enabling||Phase 1||Phase 2||Phase 3||Approval|
QLS-111 is our lead program based upon research from the laboratory of Professor Michael Fautsch at Mayo Clinic.
QLS-111, a novel formulation utilizing our ATP-sensitive potassium (KATP) channel modulator platform, lowers intraocular pressure (IOP) by relaxing vessels of the vascular and vascular-like tissues distal to the Trabecular Meshwork, thereby reducing distal outflow resistance and lowering Episcleral Venous Pressure (EVP).
Though multiple mechanisms of action exist to lower IOP in patients with glaucoma, these agents target only 3 of the 4 components of IOP as described by the Goldmann equation for IOP: the Aqueous Humor Inflow Rate (Q), Uveoscleral Outflow Rate (U), or Conventional Outflow Facility (C). There are currently no approved drugs that selectively target the reduction of EVP. This leaves a significant gap in the potential to maximally lower IOP since EVP can be the largest determinant of overall IOP.
Studies have demonstrated that treatment with QLS-111 provides persistent IOP lowering, maintains normal vascular integrity of the venous system, and does not cause hyperemia.